Manidipine


Concise Prescribing Info
Indications/Uses
HTN.
Dosage/Direction for Use
Adult : PO 10-20 mg once daily.
Dosage Details
Oral
Hypertension
Adult: 10-20 mg once daily.
Administration
Should be taken with food. Take after breakfast.
Contraindications
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
Special Precautions
Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischaemic pain following administration. Pregnancy, lactation; porphyria.
Adverse Reactions
Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
Drug Interactions
Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses. Plasma concentrations may be reduced by: carbamazepine, phenytoin, rifampicin. Plasma concentrations may be increased by cimetidine, erythromycin.
Action
Description: Manidipine is a dihydropyridine calcium-channel blocker. It causes vasodilation by blocking the entry of calcium into the arteriolar muscle cells. Manidipine also appears to have some renally protective effects.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Manidipine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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