Marixino Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Memantine HCl

Indications/Uses

Moderate to severe Alzheimer's disease.

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Dosage/Direction for Use

Adult 5 mg daily on 1st wk, 10 mg daily on 2nd wk then 15 mg daily on 3rd wk & 20 mg daily from 4th wk onwards. Max & maintenance dose: 20 mg daily. Elderly >65 yr 20 mg daily. Moderate renal impairment (CrCl 30-49 mL/min) 10 mg daily, may be increased to 20 mg daily. Severe renal impairment (CrCl 5-29 mL/min) 10 mg daily.

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Overdosage

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Administration

May be taken with or without food: Take at the same time each day.

Contraindications

Hypersensitivity.

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Special Precautions

Epilepsy, history of convulsions or predisposing factors of epilepsy. Monitor patients w/ factors that raises urine pH. Recent MI, uncompensated CHF (NYHA III-IV) or uncontrolled HTN. Avoid concomitant use w/ NMDA antagonists eg, amantadine, ketamine or dextromethorphan. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Severe hepatic impairment. Not to be used during pregnancy & lactation. Not recommended in childn <18 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Drug hypersensitivity; somnolence; dizziness, balance disorders; HTN; dyspnoea; constipation; elevated LFT; headache.

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Drug Interactions

Enhanced effects of l-dopa, dopaminergic agonists, anticholinergics. Reduced effects of barbiturates, neuroleptics. Modified effects of antispasmodic agents, dantrolene or baclofen. Risk of pharmacotoxic psychosis w/ amantadine, ketamine, dextromethorphan. Risk of increased plasma levels w/ cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine. Reduced serum level possibility of hydrochlorothiazide. Increased INR w/ warfarin.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Marixino detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DX01 - memantine ; Belongs to the class of other anti-dementia drugs.

Regulatory Classification

Presentation/Packing

Form

Marixino FC tab 10 mg

Packing/Price

56's

Marixino

memantine

Manufacturer:

KRKA

Distributor:

Pahang Pharmacy