There is limited experience with overdose of oral cladribine. Lymphopenia is known to be dose-dependent (see Precautions and Adverse Reactions).
Particularly close monitoring of haematological parameters is recommended in patients who have been exposed to an overdose of cladribine.
There is no known specific antidote to an overdose of cladribine. Treatment consists of careful observation and initiation of appropriate supportive measures. Discontinuation of MAVENCLAD may need to be considered. Because of the rapid and extensive intracellular and tissue distribution, haemodialysis is unlikely to eliminate cladribine to a significant extent.