Melphalan - oral


Patient Medicine Information
Why do I need this medicine?
Melphalan is used to treat cancer of the blood, breast and ovary.

This medicine may also be used to treat polycythaemia vera (a blood disease in which the body makes too many red blood cells).
How do I take this medicine?
Take Melphalan exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine on an empty stomach. Try to take it at the same time each day.

Swallow the tablet whole with a glass of water. Do not divide, chew or crush.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition.

Melphalan must be taken regularly for it to be effective. Continue to take this medicine even when you feel better. Do not stop taking it unless instructed by your doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Melphalan if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any of its ingredients.

Do not take this medicine if you are pregnant. If you become pregnant while on Melphalan therapy, alert your doctor immediately. This medicine may cause harm to your unborn child.

It is important that you do not get pregnant or father a child while being treated with this medicine. You must use proven birth control methods during Melphalan therapy. You may wish to discuss birth control methods with your doctor or pharmacist.

Do not breastfeed while you are being treated with this medicine.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • have recently received or currently receiving radiation therapy or chemotherapy
  • kidney disease
Be sure to check with your doctor or pharmacist before giving Melphalan to the elderly. Elderly people may be more sensitive to the side effects.

Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.

For as long as you are taking this medicine, you may need to have regular blood tests to check your body’s response to the medicine. Your doctor will advise you about how often you need to have blood tests.
What side effects could I experience?
Melphalan may cause any of the following side effects: nausea, vomiting, diarrhoea, mouth sores, muscle pain and hair loss.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swelling of the face, eyes or mouth
  • yellowing of the skin or eyes, abdominal pain, dark coloured urine, tiredness, swelling in the legs and ankles 
Melphalan will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Avoid live vaccinations during treatment with this medicine. Alert your doctor if you have been recently vaccinated or if you are planning to get vaccinated.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • ciclosporin (medicine used in organ transplant or certain immune disorders)
  • other medicines for cancer e.g. cisplatin, carmustine
  • nalidixic acid (antibiotic used to treat urinary tract infection)
This list does not include all medicines that may interact with Melphalan.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in the refrigerator, between 2-8 °C. Protect from light.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital, or pharmacy for disposal.
This information is independently developed by MIMS based on melphalan - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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