Menadione


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Vit K deficiency10 mg 6 hrly. Severe hypoprothrombinaemia 10 mg 3-4 times/day. IV Vit K Deficiency 0.03 mcg/kg/day. IM Haemorrhage or threatened haemorrhage during severe hypoprothrombinaemia 2.5-10 mg/day.
Dosage Details
Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.

Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.

Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.

Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.
Special Precautions
Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time.
Adverse Reactions
Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Decreases effects of oral anticoagulants.
Action
Description: Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin).
Pharmacokinetics:
Absorption: Requires bile for absorption from the GI tract.
Distribution: Accumulates in the liver; does not appear to cross the placenta.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Menadione from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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