Merogram Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Meropenem trihydrate

Indications/Uses

Pneumonias & nosocomial pneumonias; UTI; intra-abdominal & gynaecological infections (eg, endometritis & pelvic inflammatory disease); bacterial meningitis; septicaemia in adults & childn. Empiric treatment for presumed infections in patients w/ febrile neutropenia as monotherapy or in combination w/ antiviral or -fungal agents. Monotherapy or in combination w/ other antimicrobial agents for polymicrobial infections.

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Dosage/Direction for Use

Adult Pneumonia, UTI, gynaecological infections eg, endometritis 500 mg IV every 8 hr. Hospital-acquired pneumonias, peritonitis, presumed infections in neutropenic patient, septicaemia 1 g IV every 8 hr. Meningitis 2 g every 8 hr. Adult & adolescent Nosocomial infections due to Pseudomonas aeruginosa Up to 2 g tds. Childn >3 mth & up to 12 yr 10-20 mg/kg every 8 hr. Childn >50 kg Adult dose. Nosocomial infections due to Pseudomonas aeruginosa & meningitis 40 mg/kg every 8 hr. Febrile episodes in neutropenic patient 20 mg/kg every 8 hr.

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Overdosage

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Contraindications

Hypersensitivity to meropenem, carbapenems & other β-lactam antibacterial agents eg, penicillins or cephalosporins.

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Special Precautions

Discontinue use if hypersensitivity reactions occur. Antibiotic-associated & pseudomembranous colitis; risk of development of drug-resistant bacteria; seizures. Closely monitor hepatic function during treatment. Positive direct or indirect Coombs' test. Patients w/ restricted Na diet. Not recommended in concomitant use w/ valproic acid/Na valproate/valpromide. May affect ability to drive & use machines. Hepatic disease; renal impairment. Avoid use during pregnancy. Not to be used in lactation. Childn <3 mth. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Thrombocythaemia; headache; diarrhoea, vomiting, nausea, abdominal pain; increased transaminases, blood alkaline phosphatase & lactate dehydrogenase; rash, pruritus; inflammation, pain.

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Drug Interactions

Increased elimination t_½ & plasma conc by probenecid. Decreased valproic acid blood levels. Augmented anticoagulant effects w/ oral anticoagulants.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Merogram detailed prescribing information

Storage

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Description

View Merogram description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Other Beta-Lactams

ATC Classification

J01DH02 - meropenem ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Merogram powd for inj 1000 mg

Packing/Price

1's

Form

Merogram powd for inj 500 mg

Packing/Price

1's

Merogram

meropenem

Manufacturer:

Eugia Pharma

Distributor:

Unimed