Patient ≥90 kg 50 mg (10,000 U), ≥80 to <90 kg 45 mg (9,000 U), ≥70 to <80 kg 40 mg (8,000 U), ≥60 to <70 kg 35 mg (7,000 U), <60 kg 30 mg (6,000 U). Given as a single IV bolus over 5-10 sec.
View Metalyse overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to tenecteplase & gentamicin (trace of residue from manufacturing process). History of or current significant bleeding disorder, known haemorrhagic diathesis. Severe uncontrolled arterial HTN. Major surgery, parenchymal organ biopsy or significant trauma w/in past 2 mth, recent head or cranium trauma. Prolonged or traumatic CPR (>2 min) w/in past 2 wk. Active peptic ulceration. Arterial aneurysm & known arterial/venous malformation. Neoplasm w/ increased bleeding risk. Acute pericarditis &/or subacute bacterial endocarditis. Acute pancreatitis. Haemorrhagic stroke/stroke of unknown origin, ischaemic stroke or transient ischaemic attack (TIA) in preceding 6 mth. Concomitant oral anticoagulant therapy (INR >1.3). History of CNS damage. Severe hepatic dysfunction.
Flush preexisting IV line after Metalyse inj for proper delivery. Incompatible w/ dextrose soln. Do not mix w/ other drugs. As primary coronary recanalization treatment, patient should be transferred immediately to a coronary intervention capable facility for angiography & timely coronary intervention w/in 6-24 hr. Monitor all possible bleeding sites. Immediately terminate concomitant heparin treatment if serious bleeding occurs. Systolic BP >160 mmHg; cerebrovascular disease; known or suspected history of stroke or TIA; recent GI or GUT bleeding; recent IM inj; advanced age ie, >75 yr; low body wt <60 kg. Cerebrovascular disease. Anticoagulant treatment. Primary percutaneous coronary intervention. Arrhythmias. GPIIb/IIIa antagonists. Patients w/ left heart thrombus eg, mitral stenosis or atrial fibrillation. Hypersensitivity & anaphylactoid reactions. Pregnancy & lactation. Childn.
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 50 mg (10000 U)c2a7437a-4a4c-46de-8923-9faa0009bc74.GIF)
