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Use in Pregnancy: There is a limited amount of data from the use of METALYSE in pregnant women. Nonclinical studies performed with tenecteplase have shown bleeding with secondary mortality of dams due to the known pharmacological activity of the drug and in a few cases abortion and resorption of the foetus occurred (effects only have been observed with repeated dose administration). Tenecteplase is not considered to be teratogenic. The benefit of treatment must be evaluated against the potential risks in case of myocardial infarction during pregnancy.
Use in Lactation: It is not known if tenecteplase is excreted into human milk.
