Adjunct in senile and postmenopausal osteoporosis, Promote constructive anabolism of proteins
Adult: 5-10 mg daily, increase by 2.5 mg every 2nd or 3rd day.
Indications and Dosage
Oral
Adjunct in senile and postmenopausal osteoporosis, Promote constructive anabolism of proteins Adult: 5-10 mg daily, increase by 2.5 mg every 2nd or 3rd day.
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Contraindications
In men, prostate or breast carcinoma. Severe hepatic impairment. Hypercalcaemia, hypercalciuria. Pregnancy.
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Special Precautions
Lactation; CV disorders, renal/hepatic impairment, epilepsy, migraine, DM, conditions aggravated by fluid retention. Children. Monitor hepatic function.
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Adverse Reactions
Fluid and electrolyte retention; psychiatric effects; hypercalcaemia, impaired glucose tolerance. Men: Impotence, gynaecomastia, hirsutism, male-pattern baldness, acne, seborrhoea, oedema, cholestatic jaundice. Women: Amenorrhoea, menstrual irregularities. Children: Premature closure of epiphyses, stops linear growth; virilisation symptoms.
Potentially Fatal: Hepatotoxicity. |
Drug Interactions
May enhance effects of antidiabetics, ciclosporin, levothyroxine, warfarin. Resistance to the effects of neuromuscular blockers may occur.
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Lab Interference
May interfere with glucose tolerance and thyroid function tests.
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Action
Description: Metandienone possesses anabolic, some androgenic and little progestogenic activity.
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MIMS Class
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