Metaraminol


Concise Prescribing Info
Indications/Uses
Hypotensive states.
Dosage/Direction for Use
Adult : IV Initial: 15-100 mg via infusion; adjust dose according to BP. Severe shock: Initial: 0.5-5 mg via direct injection followed by infusion.
Dosage Details
Intravenous
Hypotensive states
Adult: Initially, 15-100 mg in 500 mL of NaCl 0.9% or dextrose 5% inj via infusion, adjusting the dose at least after 10 min to maintain BP. Severe shock: Initially, 0.5-5 mg via direct inj, followed by infusion of 15-100 mg in 500 mL of diluent.
Reconstitution
Dilute w/ 500 mL of NaCl 0.9% or dextrose 5% inj.
Incompatibility
Incompatible w/ amphotericin B, dexamethasone, prednisolone, erythromycin, hydrocortisone, methicillin, penicillin G, and thiopental.
Contraindications
Concurrent use w/ halogenated hydrocarbon anaesth.
Special Precautions
Patient w/ HTN, DM, heart or thyroid diseases, cirrhosis. May provoke relapse in patients w/ history of malaria.
Adverse Reactions
HTN, headache, tachycardia. Rarely, abscess formation, tissue necrosis, sloughing.
Potentially Fatal: Ventricular arrhythmia (in patient w/ Laennec’s cirrhosis).
MonitoringParameters
Monitor BP.
Overdosage
Symptoms: Severe HTN, headache, constricting chest sensation, nausea, vomiting, euphoria, diaphoresis, pulmonary oedema, tachycardia, bradycardia, sinus arrhythmia, atrial/ventricular arrhythmia, MI, cardiac arrest, convulsion. Management: Employ gastric lavage or induce emesis if the drug is ingested. Local ice packs may delay absorption if drug is administered via IM/SC inj. α-adrenergic blockers may be useful against HTN and arrhythmia. Parenteral diazepam may be given for convulsion.
Drug Interactions
Increased action w/ MAOI and TCA. Decreased pressor effect w/ α-adrenergic blockers. May cause ectopic arrhythmia w/ digitalis.
Potentially Fatal: Halogenated hydrocarbon anaesth, particularly cyclopropane and halothane, may increase the sensitivity of myocardium to the effects catecholamines.
Action
Description: Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic BP. It has direct actions on α- and β-adrenergic receptors causing peripheral vasoconstriction and positive inotropic effects. It also displaces norepinephrine from adrenergic stores and competitively inhibits its uptake. The overall effect is to increase cardiac output, peripheral resistance, and BP.
Onset: 1-2 min (IV); approx 10 min (IM); 5-20 min (SC).
Duration: Approx 20 min (IV); approx. 1 hr (IM).
Chemical Structure

Chemical Structure Image
Metaraminol

Source: National Center for Biotechnology Information. PubChem Database. Metaraminol, CID=5906, https://pubchem.ncbi.nlm.nih.gov/compound/Metaraminol (accessed on Jan. 22, 2020)

Storage
Store below 25˚C. Protect from light.
MIMS Class
ATC Classification
C01CA09 - metaraminol ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of hypotension.
References
Buckingham R (ed). Metaraminol Tartrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2016.

Joint Formulary Committee. Metaraminol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2016.

Metaraminol. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com/. Accessed 07/07/2016.

Disclaimer: This information is independently developed by MIMS based on Metaraminol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in