Metaxalone


Concise Prescribing Info
Indications/Uses
As an adjunct for the relief of discomfort associated with acute, painful musculoskeletal conditions
Dosage/Direction for Use
Adult : PO 800 mg 3-4 times/day.
Dosage Details
Oral
Painful muscle spasm associated with musculoskeletal conditions
Adult: As an adjunct to rest, physical therapy, and analgesics to relieve discomfort: 800 mg 3-4 times daily.
Child: >12 yr: 800 mg 3-4 times daily.
Contraindications
Patient with history of drug-induced, haemolytic or other anaemias; significantly impaired renal or hepatic function.
Special Precautions
Pregnancy; lactation; mild to moderate renal and hepatic impairment. Monitor liver function periodically during treatment. May cause CNS depression and impair mental and/or physical ability; caution when driving or operating machinery. Metaxalone is poorly tolerated by geriatric patient. Safety and efficacy have not been established in children 12 yr of age and below.
Adverse Reactions
Headache, dizziness, drowsiness, nausea, vomiting, GI upset, rash with/without pruritus, hypersensitivity reaction, nervousness/irritability, leukopenia, haemolytic anaemia, and jaundice.
Potentially Fatal: Anaphylactoid reactions.
Overdosage
Symptoms: Drowsiness, dizziness, nausea, vertigo, lethargy, agitation, slurred speech, tremor and tachycardia may occur. Treatment: Gastric lavage and supportive therapy.
Drug Interactions
Concurrent use of Metaxalone with alcohol and other CNS depressants e.g. benzodiazepines, opioids, and tricyclic antidepressants may enhance sedative effects of both drugs.
Food Interaction
Avoid alcohol and St. John's wort. Administration with high-fat meal may delay absorption, increase serum concentrations, and increase exposure of Metaxalone; which may enhance general CNS depression.
Lab Interference
May cause false-positive Benedict's test.
Action
Description: Metaxalone is a centrally acting skeletal muscle relaxant. The precise mechanism of action in humans is not known. Its effect may be associated with general CNS depression. Unlike neuromuscular blocking agents, Metaxalone does not have direct effect on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Onset: Usually within 1 hr.
Duration: Approx 4-6 hr.
Pharmacokinetics:
Distribution: Extensively distributed; apparent Vd: About 800 L.
Metabolism: Undergoes hepatic metabolism.
Excretion: Excreted in urine (as unidentified metabolites). Terminal half-life: About 4-14 hr. Apparent oral clearance: About 59-68 L/hr.
Storage
Store at 15-30°C (68-77°F).
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Metaxalone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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