Methdilazine


Concise Prescribing Info
Indications/Uses
Hypersensitivity reactions and pruritic skin disorders.
Dosage/Direction for Use
Adult : PO 8-16 mg twice daily.
Dosage Details
Oral
Hypersensitivity reactions, Pruritic skin disorders
Adult: 8-16 mg bid.
Child: 3-6 yr: 0.3 mg/kg/day, max 8 mg/day. 6-12 yr: 4 mg bid.
Administration
May be taken with or without food.
Contraindications
Neonates; narrow-angle glaucoma; GI tract/urinary outflow obstruction, paralytic ileus.
Special Precautions
Elderly; caution in driving; peptic ulcer; epilepsy; severe CV disease, benign prostatic hyperplasia; pregnancy and lactation; asthma, bronchitis; hepatic or renal impairment; Parkinson's disease.
Adverse Reactions
Drowsiness, CNS depression, paradoxical excitation (children). Dry mouth, blurring of vision; constipation, retention of urine; bradycardia followed by tachycardia and arrhythmias. GI disturbances; blood dyscrasias; giddiness; hypotension; headache; asthma; tremors; photosensitivity; jaundice; menstrual disorders.
Drug Interactions
Potentiates CNS depressant action of alcohol, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics. Antimuscarinic effects potentiated by MAOIs, atropine and TCAs. May reduce effect of levodopa.
Food Interaction
None reported.
Action
Description: Methdilazine, a phenothiazine derivative, is a sedating antihistamine with antimuscarinic and possibly some serotonin-antagonist properties.
Disclaimer: This information is independently developed by MIMS based on Methdilazine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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