Methyltestosterone


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Male hypogonadism 10-50 mg/day. Metastatic breast carcinoma in postmenopausal women 50-200 mg/day.
Dosage Details
Oral
Male hypogonadism
Adult: 10-50 mg daily.

Oral
Metastatic breast carcinoma in postmenopausal women
Adult: 50-200 mg daily.
Contraindications
Men with breast cancer, known or suspected prostate cancer. Pregnancy.
Special Precautions
Patient with CV disease, benign prostatic hyperplasia, chronic lung disease; obesity. Renal and hepatic impairment. Lactation.
Adverse Reactions
Significant: Peliosis hepatis, hepatic neoplasms, hepatocellular carcinoma, cholestatic hepatitis, jaundice, MI, stroke, DVT, pulmonary embolism, polycythaemia, oligospermia, reduced ejaculatory volume, priapism, benign prostatic hypertrophy, sleep apnoea.
Blood and lymphatic system disorders: Clotting factors suppression.
Endocrine disorders: Hirsutism.
Gastrointestinal disorders: Nausea, vomiting.
Immune system disorders: Anaphylactic reactions.
Investigations: Change in libido.
Metabolism and nutrition disorders: Hypercholesterolaemia.
Nervous system disorders: Headache, paraesthesia.
Psychiatric disorders: Depression, anxiety.
Reproductive system and breast disorders: Amenorrhoea, impotence, mastalgia, testicular atrophy.
Skin and subcutaneous tissue disorders: Acne vulgaris, androgenetic alopecia.
MonitoringParameters
Monitor LFTs, lipid profile, haemoglobin and haematocrit (at 3-6 months and annually thereafter); urine, and serum Ca. Monitor serum glucose in diabetic patients; prostate specific antigen if clinically indicated. Assess for signs of virilisation in women. Perform radiologic examination of the wrist and hand for prepubertal patients every 6 months.
Drug Interactions
Enhanced effect of anticoagulants and hypoglycaemic agent. Increased hepatotoxicity of ciclosporin. Increased plasma concentrations of oxyphenbutazone.
Lab Interference
May decrease thyroxine-binding globulin concentrations.
Action
Description: Methyltestosterone is a synthetic anabolic steroid hormone which promotes growth and development of male sex organs. It also aids in the maintenance of secondary sex characteristics in androgen-deficient men.
Pharmacokinetics:
Absorption: Absorbed from the gastrointestinal tract.
Distribution: Plasma protein binding: 98% mainly to sex hormone-binding globulin.
Metabolism: Metabolised in the liver.
Excretion: Mainly via urine (approx 90%); faeces (approx 6%). Elimination half-life: 10-100 minutes.
Chemical Structure

Chemical Structure Image
Methyltestosterone_01

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 6010, Methyltestosterone. https://pubchem.ncbi.nlm.nih.gov/compound/Methyltestosterone. Accessed Oct. 27, 2020.

Storage
Store between 15-30°C. Protect from light, moisture, and heat.
ATC Classification
G03BA02 - methyltestosterone ; Belongs to the class of 3-oxoandrosten (4) derivative androgens used in androgenic hormone preparations.
References
Anon. Methyltestosterone. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 08/09/2020.

Anon. Methyltestosterone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/09/2020.

Buckingham R (ed). Methyltestosterone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/09/2020.

Methitest Tablets (Amneal Pharmaceuticals of New York LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2020.

Methyltestosterone Capsule (Amneal Pharmaceuticals of New York LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/09/2020.

Disclaimer: This information is independently developed by MIMS based on Methyltestosterone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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