mivacurium chloride




Zuellig Pharma
Concise Prescribing Info
Mivacurium Cl
Adjunct to general anesth to relax skeletal muscles, facilitate tracheal intubation & mechanical ventilation.
Dosage/Direction for Use
IV inj Tracheal intubation Adult 0.2 mg/kg over 30 sec or 0.25 mg/kg as divided dose (0.15 mg/kg followed by 0.1 mg/kg after 30 sec). Bolus dose: 0.07-0.25 mg/kg. Childn 7 mth-12 yr & infant 0.2 mg/kg. Bolus dose: 0.1-0.2 mg/kg over 5-15 sec. Maintenance: 0.1 mg/kg. Infant 2-6 mth Bolus dose: 0.1-0.15 mg/kg over 5-15 sec. Maintenance: 0.1 mg/kg. IV infusion Adult 8-10 mcg/kg/min. Dose adjustment may be given in increments approx 1 mcg/kg/min. Childn 2-12 yr Approx 13-14 mcg/kg/min (range: 5-31 mcg/kg/min) under halothane or narcotic anaesth, 7-23 mth Approx 11 mcg/kg/min (range: 3-26 mcg/kg/min). Infant 2-6 mth Approx 11 mcg/kg/min (range: 4-24 mcg/kg/min).
Hypersensitivity. Patients known to be homozygous for atypical plasma cholinesterase gene.
Special Precautions
Hypersensitivity to other neuromuscular blocking agents. Increased sensitivity to effects of histamine. Genetically determined abnormalities of plasma cholinesterase; severe generalized tetanus, TB & other severe or chronic infections; chronic debilitating disease, malignancy, chronic anaemia, malnutrition; myxoedema, collagen diseases; decompensated heart disease; peptic ulcer; burn patients; iatrogenic. Severe acid-base or electrolyte abnormalities; myasthenia gravis, other forms of neuromuscular disease, cachectic patients; hypovolaemic; malignant hyperthermia-susceptible patients. Reversal of neuromuscular block. Not to be mixed w/ highly alkaline soln. May affect ability to drive & use machines. End-stage hepatic failure; acute, chronic or end-stage renal failure. Not to be used during pregnancy. Lactation. Elderly.
Drug Interactions
Potentiated by inhalational anaesth eg, enflurane, isoflurane, sevoflurane, halothane. Increased magnitude &/or duration w/ aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin; propranolol, Ca-channel blockers, lidocaine, procainamide, quinidine; furosemide, possibly thiazides, mannitol, acetazolamide; Mg & lithium salts; ketamine; trimetaphan, hexamethonium. Prolonged neuromuscular-blocking action w/ drugs reducing plasma cholinesterase activity eg, anti-mitotic drugs, MAOIs, ecothiopate iodide, pancuronium, organophosphates, anticholinesterases, certain hormones, bambuterol, SSRI. Aggravated or unmasked latent myasthenia gravis w/ β-blockers, anti-arrhythmics, antirheumatics, trimetaphan, chlorpromazine, steroids, phenytoin, lithium. Prolonged & complex block w/ suxamethonium Cl.
MIMS Class
Neuromuscular Blocking Agents
ATC Classification
M03AC10 - mivacurium chloride ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.
Mivacron soln for inj 20 mg/10 mL
5 × 1's
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