Cumulative dose: Up to 2,000 mg should be considered based on body Fe deficit. IV bolus inj Up to 500 mg administered at rate 250 mg/min up to 3 times wkly. IV drip infusion Up to 20 mg/kg single infusion. Doses up to 1,000 mg should be given >15 min; doses >1,000 mg should be given ≥30 min for not more than once wkly. HD patient May be given directly into venous limb of dialyser. Therapeutic response can be seen w/in few days.
View Monofer overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to ferric derisomaltose or other parenteral Fe products. Non-Fe deficiency anaemia (eg, haemolytic anaemia), Fe overload or disturbances in Fe utilisation (eg, haemochromatosis, haemosiderosis).
Hypersensitivity reactions may occur. Not to be used in patients w/ ongoing bacteraemia. History of severe asthma, eczema or other atopic allergy. Immune or inflammatory conditions eg, SLE, RA. Acute or chronic infection. Avoid too rapid IV inj. Paravenous leakage. Monitor Fe status to avoid Fe overload. Hepatic impairment. Not to be used during 1st trimester of pregnancy. Not recommended in childn & adolescents <18 yr.
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