Motilium

Motilium

domperidone

Manufacturer:

Janssen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Domperidone
Indications/Uses
Symptomatic relief of nausea & vomiting of functional, organic, infectious or dietary origin, induced by radio- or drug therapy & dopamine agonist used in Parkinson's disease.
Dosage/Direction for Use
Tab Adult & adolescent ≥12 yr, ≥35 kg & childn <12 yr, ≥35 kg 1 tab tds-qds. Max: 40 mg daily. Oral susp Adult & adolescent ≥12 yr, ≥35 kg & childn <12 yr, ≥35 kg 10 mL tds-qds. Max: 40 mg daily. Adult & adolescent ≥12 yr, <35 kg 0.25 mg/kg tds-qds. Max: 35 mg daily.
Administration
Should be taken on an empty stomach: Take 15-30 min before meals.
Contraindications
Hypersensitivity. Prolactinoma. Patients w/ existing prolongation of cardiac conduction interval, significant electrolyte disturbances or underlying cardiac diseases eg, CHF. GI haemorrhage, mechanical obstruction or perforation. Co-administration w/ QT-prolonging drugs, potent CYP3A4 inhibitors. Moderate or severe hepatic impairment.
Special Precautions
Discontinue use if signs & symptoms of cardiac arrhythmia occurs. Increased risk of serious ventricular arrhythmias or sudden cardiac death; proarrhythmia. Concomitant use w/ QT-prolonging drugs, potent CYP3A4 inhibitors, antacids or antisecretory agents. Lactose/sorbitol intolerance, galactosemia or glucose/galactose malabsorption. May affect ability to drive & use machines. Severe renal impairment. Pregnancy. Not recommended during lactation. Infant & childn <12 yr, <35 kg.
Adverse Reactions
Anaphylactic reactions; agitation, nervousness; dizziness, extrapyramidal disorder, convulsion; ventricular arrythymias, QTc prolongation, Torsade de pointes, sudden cardiac death; angioedema; urinary retention; abnormal liver function test, increased blood prolactin.
Drug Interactions
Increased plasma levels w/ CYP3A4 inhibitors. Antagonized anti-dyspeptic effect w/ anticholinergic drugs eg, dextromethorphan, diphenhydramine.
ATC Classification
A03FA03 - domperidone ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Motilium FC tab 10 mg
Packing/Price
500's
Form
Motilium oral susp 1 mg/mL
Packing/Price
100 mL x 1's
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