Motilium

Motilium Dosage/Direction for Use

domperidone

Manufacturer:

Janssen

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
It is recommended to take oral MOTILIUM 15-30 minutes before meals. If taken after meals, absorption of the drug is somewhat delayed.
Adults and adolescents ≥ 12 years of age and weighing ≥35 kg and children <12 years of age and weighing ≥ 35 kg: The dose of MOTILIUM should be the lowest effective dose for the individual situation (typically 30 mg/day) and can be increased if necessary to a maximum daily oral dose of 40 mg.
Usually, the maximum treatment duration should not exceed one week for the treatment of acute nausea and vomiting. If nausea and vomiting persists for longer than one week, patients should consult their physician. For other indications, the initial duration of treatment is up to four weeks. If treatment exceeds four weeks, patients should be reevaluated and the need for continued treatment reassessed. (See Table 2.)

Click on icon to see table/diagram/image

Adults and adolescents (≥ 12 years of age) weighing < 35 kg: The dose of MOTILIUM should be the lowest effective dose. The total daily dose is dependent on weight (see table as follows).
Usually, the maximum treatment duration should not exceed one week for the treatment of acute nausea and vomiting. For other indications, the initial duration of treatment is up to four weeks. If treatment exceeds four weeks, patients should be reevaluated and the need for continued treatment reassessed. Film-coated tablets and orodispersible tablets are unsuitable for use in adults and adolescents weighing less than 35 kg. (See Table 3.)

Click on icon to see table/diagram/image

Infants and children < 12 years of age and weighing < 35 kg: The efficacy of MOTILIUM has not been established in infants and children < 12 years of age and weighing < 35 kg (see Pharmacology: Pharmacodynamics: Clinical Studies under Actions).
Renal impairment: Since the elimination half-life of domperidone is prolonged in severe renal impairment (serum creatinine > 6 mg/100 mL, i.e. > 0.6 mmol/L), the dosing frequency of MOTILIUM should be reduced to once or twice daily, depending on the severity of the impairment, and the dose may need to be reduced. Patients with severe renal impairment should be reviewed regularly (see Pharmacology: Pharmacokinetics under Actions).
Hepatic impairment: MOTILIUM is contraindicated for patients with moderate (Child-Pugh 7 to 9) or severe (Child-Pugh >9) hepatic impairment (see Contraindications). Dose adjustment is not required for patients with mild (Child-Pugh 5 to 6) hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
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