Mycamine

Mycamine Dosage/Direction for Use

micafungin

Manufacturer:

Astellas Pharma

Distributor:

DKSH
Full Prescribing Info
Dosage/Direction for Use
MYCAMINE should be administered once daily by intravenous infusion. The dosage depends on the indication and body weight of the patient as shown in Tables 3 and 4 as follows. (See Table 3.)

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Treatment duration: Invasive candidiasis: The treatment duration of Candida infection should be a minimum of 14 days. The antifungal treatment should continue for at least one week after two sequential negative blood cultures have been obtained and after resolution of clinical signs and symptoms of infection.
Oesophageal candidiasis: For the treatment of oesophageal candidiasis, MYCAMINE should be administered for at least one week after resolution of clinical signs and symptoms.
Prophylaxis of Candida infections: For prophylaxis of Candida infection, MYCAMINE should be administered for at least one week after neutrophil recovery. (See Tables 4 and 5.)

Click on icon to see table/diagram/image


Click on icon to see table/diagram/image

Treatment duration: Invasive candidiasis: The treatment duration of Candida infection should be a minimum of 14 days and should continue for at least one week after two sequential negative blood cultures have been obtained and after resolution of clinical signs and symptoms of infection.
Prophylaxis of Candida infections: For prophylaxis of Candida infection, MYCAMINE should be administered for at least one week after neutrophil recovery. Experience in patients less than two years of age is limited.
Patients with hepatic impairment: No dosage adjustment is required in patients with mild to severe hepatic impairment (see PHARMACOLOGY: Pharmacokinetics: Pharmacokinetic characteristics in special populations under Actions).
Patients with renal impairment: No dosage adjustment is required in patients with renal impairment (creatinine clearance <30mL/min) (see PHARMACOLOGY: Pharmacokinetics: Pharmacokinetic characteristics in special populations under Actions).
Instructions for reconstitution and dilution: MYCAMINE must not be mixed or co-infused with any other medicinal products except those mentioned as follows. MYCAMINE has been shown to precipitate when mixed directly with a number of other commonly used medications.
Using aseptic techniques at room temperature, MYCAMINE should be reconstituted and diluted as follows: Remove the plastic cap from the vial and disinfect the stopper with alcohol.
Five mL of sodium chloride 9 mg/mL (0.9%) solution for infusion or glucose 50 mg/mL (5%) solution for infusion (taken from a 100 mL bag/bottle) should be aseptically and slowly injected into each vial along the side of the inner wall. Although the concentrate will foam, every effort should be made to minimise the amount of foam generated. A sufficient number of vials of MYCAMINE should be reconstituted to obtain the required dose as shown in Table 6 as follows.
The vial should be rotated gently. Do not shake. The powder will dissolve completely. The concentrate should be used immediately for further dilution. The product is for single use in one patient only. Discard any residue.
All of the reconstituted concentrate should be withdrawn from each vial and returned into the infusion bag/bottle from which it was originally taken. The diluted infusion solution should be used immediately.
The infusion bag/bottle should be gently inverted to disperse the diluted solution but NOT agitated in order to avoid foaming. Do not use if the solution is cloudy or has precipitated.
The infusion bag/bottle containing the diluted infusion solution should be inserted into a closable opaque bag for protection from light. (See Table 6.)

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Administration: An existing intravenous line should be flushed with sodium chloride 0.9% solution prior to infusion. Administer the reconstituted and diluted MYCAMINE solution intravenously over approximately one hour.
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