Nalorphine


Concise Prescribing Info
Indications/Uses
Reversal of opioid-induced respiratory depression.
Dosage/Direction for Use
Adult : IV/IM As hydrobromide or HCl: 5-10 mg, repeat every 10-15 mins as needed until respiration is restored. Max: 40 mg.
Dosage Details
Intramuscular
Reversal of opioid-induced respiratory depression
Adult: As hydrobromide or hydrochloride: 5-10 mg repeated every 10-15 minutes as required until respiration is restored. Max dose: 40 mg.

Intravenous
Reversal of opioid-induced respiratory depression
Adult: As hydrobromide or hydrochloride: 5-10 mg repeated every 10-15 minutes as required until respiration is restored. Max dose: 40 mg.
Special Precautions
Patients physically dependent on opioids or who have received large doses of opioids (acute withdrawal syndrome may be precipitated). May exacerbate respiratory depression induced by alcohol or other non-opioid depressant. Pregnancy and lactation. Cardiac disease or patients receiving cardiotoxic medications.
Adverse Reactions
Drowsiness, respiratory depression, miosis, dysphoria, lethargy.
Action
Description: Nalorphine is an opioid antagonist, with properties similar to naloxone. It also has some agonist properties.
Pharmacokinetics:
Absorption: Absorbed after oral admin.
Metabolism: Undergoes extensive first-pass metabolism.
Excretion: Via urine mainly as metabolites and glucuronide conjugates with about 2-6% of a dose as unchanged drug.
Storage
Store at 25 °C, excursions at 15-30°C permitted. Protect from light.
Disclaimer: This information is independently developed by MIMS based on Nalorphine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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