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Neurotoxic, Ototoxic or Nephrotoxic Drugs: Since neurotoxic, ototoxic or nephrotoxic effects may be additive, concurrent and/or sequential use of an aminoglycoside and other drugs (administered systemically, orally or topically) with similar toxic potentials (e.g., other aminoglycosides, acyclovir, amphotericin B, bacitracin, capreomycin, cephalosporins, colistin, cisplatin, methoxyflurane, polymyxin B, vancomycin) should be avoided, if possible.
General Anesthetics and Neuromuscular Blocking Agents: Concurrent use of an aminoglycoside with general anesthetics or neuromuscular blocking agents (e.g., succinylcholine, tubocurarine) may potentiate neuromuscular blockade and cause respiratory paralysis.
