Pharmacology: Pharmacodynamics: Netilmicin Sulfate is a semi-synthetic, water-soluble antibiotic of aminoglycoside group.
Netilmicin is a rapidly acting bactericidal, it probably acts by inhibiting normal protein synthesis in susceptible organisms, such as Escherichia coli, Klebsiella spp., Citrobacter spp., Proteus mirabilis, P. vulgaris, P. morganii, P. rettgeri, Pseudomonas aeruginosa, Proteus spp. (indole-positive and indole-negative).
Netilmicin is also active in vitro against isolates of Hemophilus influenzae, Shigella spp., Salmonella spp., Neisseria spp., Penicillinase and non penicillinase-producing Staphylococcus including methicillin-resistant strains. Some strains of Providencia spp., Acinetobacter spp. and Aeromonas spp. Many strains of organism which are resistant to other aminoglycosides, such as kanamycin, gentamicin, tobramycin.
Combination of netilmicin and penicillin G has a synergistic bactericidal effect against most strains of Streptococcus faecalis (enterococcus).
The combination effect of netilmicin and carbenicillin or ticarcillin is synergistic for many strains of Pseudomonas aeruginosa.
Pharmacokinetics: Absorption: Netilmicin is poorly absorbed from the intact GI tract following oral administration.
It is rapidly and completely absorbed following IM administration.
Distribution: Netilmicin rapidly distributes into tissues, sputum and pericardial, synovial and peritoneal fluids. The volume of distribution of netilmicin is approximately 20% of body weight. It is reported 0-30% protein bound.
Elimination: The plasma elimination half-life of netilmicin is about 2-2.5 hours following IV or IM administration of a single dose in adults with normal renal function.