Previous malignant disease; benign intracranial HTN, growth hormone deficiency secondary to intracranial lesion; incipient hypothyroidism; scoliosis, endocrine disorders & short stature; impaired glucose tolerance, overt DM, obesity, history of DM, preexisting type 1 or 2 DM; history of upper airway obstruction, sleep apnoea, unidentified resp infection. Monitor growth of hands & feet in Turner syndrome patients. Measure IGF-1 levels prior to & regularly thereafter. Perform careful otological evaluation in girls w/ Turner syndrome. Regularly test thyroid function & receive replacement therapy when indicated. Long-term treatment (>10 yr). Monitor renal function during treatment especially in patients w/ chronic renal disease. Pregnancy & lactation. Childn w/ Prader-Willi syndrome. Elderly >60 yr.