Increased risk of CAD in women w/ presence of other predisposing factors eg, smoking, hypercholesterolaemia, obesity, diabetes, history of pre-eclamptic toxaemia & increasing age; congenital abnormalities including heart & limb defects. Discontinue at least 4 wk before elective surgery or during prolonged immobilization periods. Discontinue use if gradual or sudden, partial or complete loss of vision or any evidence of ocular changes, onset or aggravation of migraine or development of recurrent, persistent or severe headache, suspicion of thrombosis or infarction, significant rise in BP or if jaundice occurs. Benign & malignant hepatic tumours, thrombosis, embolism or haemorrhage. Epilepsy, history of migraine or cardiac or renal dysfunction. Contact lens wearers. Women w/ impaired carbohydrate tolerance, depression, gallstones, past history of liver disease, varicose veins, HTN, asthma or any disease that is prone to worsen during pregnancy. Lactation.
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