There have been very rare cases of fungaemia reported mostly in patients with central venous catheter, critically ill or immunocompromised patients, most often resulting in pyrexia. In most cases, the outcome has been satisfactory after cessation of treatment by Saccharomyces boulardii, administration of antifungal treatment and removal of the catheter when necessary. However, the outcome was fatal in some critically ill patients (see Contraindications and Side Effects).
With diarrhea lasting longer than 2 days or accompanied by blood in the stool or a rise in temperature, patient should consult a doctor. With diarrheal diseases, especially in children, attention must be paid to the use of fluid and electrolytes as the most important therapeutic measure.
Saccharomyces boulardii is a living microorganism, which under inappropriate conditions, that occur in patients with an impaired immune defense system, may cause systemic fungal infections by migration from the intestinal tract in the blood or by external contamination of central venous catheter. Isolated cases of such fungal infections have been reported in hospitalized patients with central venous catheter suffering from several basic diseases.