Norvasc

Norvasc

amlodipine

Manufacturer:

Viatris

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Amlodipine besilate
Indications/Uses
1st-line treatment of HTN & myocardial ischemia whether due to fixed obstruction (stable angina) &/or vasospasm/vasoconstriction (Prinzmetal's variant angina) of coronary vasculature. Monotherapy or in combination w/ other antianginal drugs in patients w/ angina refractory to nitrates &/or β-blockers.
Dosage/Direction for Use
Initially 5 mg once daily, may be increased to max: 10 mg.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to dihydropyridines.
Special Precautions
NYHA class III & IV heart failure of non-ischaemic etiology. Hepatic impairment. Pregnancy & lactation. Childn.
Adverse Reactions
Headaches, dizziness, somnolence; palpitations; flushing; abdominal pain, nausea; oedema, fatigue.
Drug Interactions
Increased exposure to simvastatin. Increased BP-lowering effects w/ grapefruit or grapefruit juice. Increased systemic exposure in elderly hypertensive patients w/ diltiazem. Increased plasma conc by strong CYP3A4 inhibitors eg, ketoconazole, itraconazole, ritonavir. Increased risk of hypotension w/ clarithromycin. Decreased plasma conc by CYP3A4 inducers eg, rifampicin, Hypericum perforatum. Affects trough conc of cyclosporin. Increased tacrolimus blood levels. Increased exposure of mTOR inhibitors.
MIMS Class
Calcium Antagonists / Anti-Anginal Drugs
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Norvasc tab 10 mg
Packing/Price
100's;30's
Form
Norvasc tab 5 mg
Packing/Price
100's;30's
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