Invasive aspergillosis in patients w/ disease refractory to amphotericin B or intolerant to these drugs. Fusariosis, zygomycosis, coccidioidomycosis, chromoblastomycosis & mycetoma in patients w/ disease refractory to other therapy or intolerant to other therapy. Prophylaxis of invasive fungal infections in patients w/ acute myelogenous leukaemia (AML) or myelodysplastic syndrome (MDS), haematopoietic stem cell transplant recipients & who are at high risk of developing these infections. Oral susp: Oropharyngeal candidiasis in immunocompromised adults.
Tab Refractory invasive fungal infections (IFI)/intolerant patient w/ IFI & prophylaxis of invasive fungal infection Loading dose: 300 mg bd on 1st day then 300 mg once daily thereafter. Duration of therapy: AML or MDS Prophylaxis should start several days before the anticipated onset of neutropenia & continue for 7 days after neutrophil count rises >500 cells/mm3. Oral suspRefractory IFI/intolerant patient w/ IFI 400 mg bd; administer 200 mg qds in patients w/ limited oral intake. Oropharyngeal candidiasis in HIV-infected patient Loading dose: 200 mg once daily on 1st day then 100 mg once daily for 13 days. Oropharyngeal candidiasis refractory to itraconazole or fluconazole in HIV-infected patient 400 mg bd. Prophylaxis of invasive fungal infections 200 mg tds.
View Noxafil overdosage for action to be taken in the event of an overdose.
Administration
Tab: May be taken with or without food: Swallow whole, do not crush/chew/break/dissolve. Oral susp: Should be taken with food: Take w/ a full meal or w/ a liqd nutritional supplement in patients who cannot eat a full meal.
Hypersensitivity to other azoles. Pro-arrhythmic conditions eg, congenital or acquired QTc prolongation, cardiomyopathy, sinus bradycardia, existing symptomatic arrhythmias. Monitor & correct electrolyte disturbances prior to & during therapy. Concomitant use w/ drugs known to prolong QTc interval, vincristine, adrenal steroid hormones. Severe hepatic & renal impairment. Women of childbearing potential must use effective contraceptive during & for at least 2 wk after therapy. Not to be used during pregnancy & lactation. Not to be used in childn <18 yr. Tab: Not for oropharyngeal candidiasis.
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