Previous history of bronchial asthma or allergic disease. SLE & mixed connective tissue disease. Renal impairment, hepatic dysfunction. HTN, heart failure. Long-term high doses treatment. History of GI disease eg, ulcerative colitis, Crohn's disease. Exfoliative dermatitis, Stevens-Johnson syndrome. Discontinue use at 1st appearance of skin rash, mucosal lesions or any hypersensitivity. Concomitant oral corticosteroids, anticoagulants, SSRIs, anti-platelet drugs. Avoid concomitant NSAIDs including COX-2 selective inhibitors. Avoid during 1st 6 mth & not to be used in last trimester of pregnancy. Lactation. Elderly.
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