Hypersensitivity to ibuprofen, aspirin or other NSAIDs. Active or history of peptic ulceration. Patients who undergone CABG surgery & revascularization procedures. Severe heart, renal or hepatic failure. Last trimester of pregnancy.
Discontinue use at 1st appearance of skin rash, mucosal lesions or any hypersensitivity. Previous history of bronchial asthma or allergic disease. SLE & mixed connective tissue disease. Renal impairment, hepatic dysfunction. HTN, heart failure. Long-term high doses treatment. History of GI disease eg, ulcerative colitis, Crohn's disease. Exfoliative dermatitis, Stevens-Johnson syndrome. Concomitant oral corticosteroids, anticoagulants, SSRIs, anti-platelet drugs. Avoid concomitant NSAIDs including COX-2 selective inhibitors. Avoid during 1st 6 mth & not to be used in last trimester of pregnancy. Lactation. Elderly.