Octanate

Octanate

factor viii

Manufacturer:

Octapharma

Distributor:

Pharmaniaga Marketing
Concise Prescribing Info
Contents
Human coagulation factor VIII
Indications/Uses
Treatment & prophylaxis of bleeding in patients w/ haemophilia A (congenital factor VIII deficiency).
Dosage/Direction for Use
IV Early haemarthrosis, muscle or oral bleeding 20-40 IU/dL every 12-24 hr for at least 1 day or until resolved. More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL every 12-24 hr for ≥3-4 days or until resolved. Life-threatening bleeds (eg, head injury, throat or severe GI bleeding) 60-100 IU/dL every 8-24 hr until resolved. Minor surgery (eg, tooth extraction) 30-60 IU/dL every 24 hr for at least 1 day. Major surgery (pre- & post-op) 80-100 IU/dL every 8-24 hr. Long-term prophylaxis against bleeding in patients w/ severe haemophilia A 20-60 IU/kg at intervals of 2-3 days.
Contraindications
Known allergic reactions.
Special Precautions
Discontinue use if early signs of hypersensitivity reactions eg, hives, generalised urticaria, chest tightness, wheezing, hypotension & anaphylaxis occur. Appropriate vaccination against hepatitis A & B for patients in receipt of plasma derived FVIII concentrates. Monitor for the development of FVIII inhibitors. Pregnancy & lactation. Childn <6 yr.
Adverse Reactions
Fever, hypersensitivity or allergic reactions eg, rigors, flushing, generalised urticaria, headaches, hives, hypotension, lethargy, nausea, restlessness, tachycardia, chest tightness, tingling, vomiting, wheezing, angioedema, burning & stinging at infusion site.
MIMS Class
ATC Classification
B02BD02 - coagulation factor VIII ; Belongs to the class of blood coagulation factors. Used in the treatment of hemorrhage.
Presentation/Packing
Form
Octanate powd for infusion 1,000 IU/10 mL
Packing/Price
1's
Form
Octanate powd for infusion 250 IU/5 mL
Packing/Price
1's
Form
Octanate powd for infusion 500 IU/10 mL
Packing/Price
1's
Form
Octanate powd for infusion 100 IU/mL
Packing/Price
1's
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