Ondavell

Ondavell

ondansetron

Manufacturer:

Novell Pharma

Distributor:

Averroes Pharma
Concise Prescribing Info
Contents
Ondansetron
Indications/Uses
Management of cytotoxic chemo- & radiotherapy induced nausea & vomiting (CINV & RINV). Prevention & treatment of post-op nausea & vomiting (PONV).
Dosage/Direction for Use
CINV & RINV Adult 8 mg IV or IM prior to treatment, may be followed by 2 additional 8 mg IV or IM doses 2-4 apart or by constant 1 mg/hr infusion for up to 24 hr. Highly emetogenic chemotherapy Max initial dose: 16 mg IV infused over 15 min, may be enhanced w/ single IV dose of dexamethasone Na phosphate 20 mg prior to chemotherapy. Elderly ≥75 yr Initially not >8 mg infused over 15 min, may be followed by 2 doses of 8 mg infused over 15 min & given no <4 hr apart; 65-74 yr Initially 8 or 16 mg infused over 15 min, may be followed by 2 doses of 8 mg infused over 15 min & given no <4 hr apart. CINV Childn & adolescent 3-17 yr, >1.2 m2 5 mg/m2 or 8 mg IV + 8 mg tab after 12 hr on day 1, then 8 mg tab every 12 hr on days 2-6; ≥0.6 m2 to ≤1.2 m2 5 mg/m2 IV + 4 mg tab after 12 hr on day 1, then 4 mg tab every 12 hr on days 2-6; >10 kg Up to 3 doses of 0.15 mg/kg IV every 4 hr on day 1, then 4 mg tab every 12 hr on days 2-6. Prevention & treatment of established PONV Adult 4 mg single IM dose or slow IV inj at anaesth induction. Childn & adolescent 3-17 yr 0.1 mg/kg by slow IV inj not <30 sec up to max: 4 mg prior to or after anesth induction, or after surgery. Moderate or severe hepatic impairment Not to exceed 8 mg total daily dose.
Contraindications
Hypersensitivity. Concomitant use w/ apomorphine.
Special Precautions
Hypersensitivity to other selective 5-HT3 antagonists. Signs of subacute intestinal obstruction. Transient ECG changes including prolonged QT interval. Women of childbearing potential should use effective contraception during & 2 days after treatment. Not recommended during pregnancy & lactation.
Adverse Reactions
Headache, sensation of warmth or flushing, hiccups, constipation.
Drug Interactions
Increased oral clearance & decreased blood conc w/ potent CYP3A4 inducers ie, phenytoin, carbamazepine, rifampicin. Reduced analgesic effect of tramadol.
MIMS Class
Antiemetics / Supportive Care Therapy
ATC Classification
A04AA01 - ondansetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
Presentation/Packing
Form
Ondavell soln for inj 2 mg/mL
Packing/Price
2 mL x 5 × 1's;4 mL x 5 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in