Pharmacology: Synovial fluid, which is viscoelastic due to the presence of hyaluronic acid, is found in all synovial joints where it ensures normal, painless movement due to its lubricating and shock-absorbing properties.
It is also responsible for the nutrition of the cartilage. In degenerative joint disorders such as osteoarthritis, the viscoelaticity of the synovial fluid is markedly reduced thereby decreasing its lubricating and shock-absorbing functions. This increases mechanical loading of the joint and cartilage destruction which ultimately results in pain and restricted mobility of the affected joint. Supplementing this synovial fluid with intraarticular injections of highly purified hyaluronic acid can ameliorate the viscoelastic properties of synovial fluid. This improves its lubricating and shock-absorbing functions and reduces mechanical overload of the joint.
As a rule this results in a decrease in pain and an improvement in joint mobility which may last for several months after the treatment cycle.
Ostenil Plus is a transparent solution of natural and highly purified sodium hyaluronate obtained by fermentation and is devoid of animal protein. OSTENIL PLUS also contains mannitol, a free radical scavenger, which helps to stabilise the chains of sodium hyaluronate. In biocompatibility studies, OSTENIL PLUS was found to be particularly safe.