Oteracil potassium


Concise Prescribing Info
Indications/Uses
Adjunct to tegafur in the treatment of resectable gastric carcinoma.
Dosage/Direction for Use
Adult : PO W/ tegafur and gimeracil: 40 mg/m2 twice daily for 7 days pre-op and for 15 days post-op starting on day 15 post-op.
Dosage Details
Oral
Resectable gastric carcinoma
Adult: In combination with tegafur and gimeracil: 40 mg/m2 bid for 7 days pre-operatively and for 15 days after operation starting on day 15 after operation.
Action
Description: Oteracil potassium is used as part of an antineoplastic combination product that includes tegafur and gimeracil. Oteracil inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and possibly reduces 5-FU induced GI adverse effects.
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