Oxybuprocaine


Concise Prescribing Info
Indications/Uses
Surface anaesth.
Dosage/Direction for Use
Adult : Ophth As 0.4% soln: Tonometry: Instill 1 drop 1 min before measurement. Contact lens fitting: Additional drop 90 sec before fitting. Removal of foreign body or minor surgery: Instill 3 drops at 90 sec interval. Pterygium surgery: Instill 1 drop/min for 10 doses.
Dosage Details
Ophthalmic
Surface anaesthesia
Adult: As 0.4% soln: For tonometry: Instill 1 drop into the conjunctival sac 1 min before measurement. For contact lens fitting: Additional drop 90 sec before fitting. For removal of foreign body or minor surgery: Instill 3 drops at 90 sec interval. For pterygium surgery: Instill 1 drop every min for 10 doses.
Child: Same as adult dose.
Contraindications
Preterm neonate.
Special Precautions
Patient w/ eye infection. Prolonged use. Childn. Pregnancy and lactation.
Adverse Reactions
Significant: Corneal damage, keratitis and tolerance (w/ prolonged use).
GI: Occasional nausea, vomiting, dysphagia.
Ophthalmologic: Transient stinging and burning sensation, blurred vision; stromal infiltration, candida/disciform keratitis, oedema, peripheral corneal formation, epithelial corneal damage (frequent use).
Immunologic: Allergic reactions (e.g. contact allergy, urticaria, angioneurotic oedema).
Patient Counseling Information
This drug may cause transient blurring of vision, if affected, do not drive or operate machinery. Avoid dust and bacterial contamination of anaesthetised eye.
Action
Description: Oxybuprocaine, a para-aminobenzoic acid ester, is a local, surface anaesthesia. It reversibly inhibits the conduction of nerve impulses along nerve axons and the excitability of nociceptors thereby reducing pain sensation.
Onset: Approx 1 min.
Duration: 20-40 min.
Pharmacokinetics:
Absorption: Rapidly and readily absorbed into systemic circulation.
Metabolism: Metabolised by plasma cholinesterases; to a lesser extent, metabolised in the liver mainly to 3-butoxy-4-aminobenzoic acid and other metabolites.
Chemical Structure

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Storage
Store between 2-8°C. Do not freeze. Protect from light.
ATC Classification
S01HA02 - oxybuprocaine ; Belongs to the class of local ophthalmologic anesthetics.
Disclaimer: This information is independently developed by MIMS based on Oxybuprocaine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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