Oxyphenbutazone


Concise Prescribing Info
Contraindications
Blood disorders; peptic ulcer; inflammatory bowel disease; cardiovascular, pulmonary or thyroid disease; severe hepatic or renal impairment; porphyria; lactation.
Special Precautions
Perform regular blood-cell counts; monitor renal and hepatic function; elderly; hypertension; infection.
Adverse Reactions
GI disturbances, GI bleeding, ulcer, stomatitis; sodium and fluid retention; rash; hepatitis. Exacerbation of asthma; parotid swelling; hypersensitivity reactions; nephrotoxicity; photosensitivity.
Potentially Fatal: Severe myelosuppression; aplastic anaemia.
Drug Interactions
Reduces antihypertensive actions of ACE inhibitors, β-blockers and diuretics. Raises levels of phenytoin, lithium. Serum concentrations increased by methandienone. Absorption delayed by TCAs.
Potentially Fatal: Enhances activities of oral anticoagulants, hydantoins and oral hypoglycaemic agents.
Action
Description: Oxyphenbutazone is a p-hydroxy analog and one of the active metabolites of phenylbutazone with a marked anti-inflammatory effect. Its potential for serious toxicity, however, limits its use in long-term therapy.
Disclaimer: This information is independently developed by MIMS based on Oxyphenbutazone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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