Paliperidone - intramuscular

Patient Medicine Information
Why do I need this medicine?
Paliperidone is used to treat schizophrenia (an illness that causes changes in perception, thoughts and behaviour).

This medicine may also be used on its own or together with other medicines to treat schizoaffective disorder (a mental illness that can be experienced in addition to the symptoms of schizophrenia).

Paliperidone helps relieve symptoms common in schizophrenia and schizoaffective disorder, such as agitation, distress, distorted thinking and emotional instability.
How do I use this medicine?
Paliperidone is to be given by deep intramuscular (into the muscle) injection. Your doctor or nurse will administer the injection for you.

The dose of Paliperidone will be decided by your doctor. Your doctor will advise you on the treatment regimen depending on your condition, response and tolerability to this medicine.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Paliperidone.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Alert your doctor immediately if you are allergic (rashes, breathlessness, swollen eyes) to Paliperidone or similar medicine such as risperidone.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • neuroleptic malignant syndrome (a neurological disorder characterised by muscle rigidity, fever and blood pressure changes)
  • heart or blood vessel disease e.g. heart rhythm disorder, heart failure, heart attack, stroke
  • tardive dyskinesia (a condition which causes uncontrollable twitching movements of the mouth, tongue and limbs)
  • kidney disease
  • liver disease
  • diabetes or at risk for diabetes e.g. obesity, family history
  • history of blood clot disorder
  • epilepsy (fits or seizures), including those with history of seizures, head trauma, brain damage, alcoholism
  • hyperprolactinaemia (high levels of the hormone prolactin in your blood)
  • dementia (group of symptoms affecting thinking and social abilities)
  • Parkinson’s disease (a brain disease that affects movement)
If you are going for an operation such as an eye surgery, inform your doctor that you are using Paliperidone.

Paliperidone may cause your white blood cell count to drop drastically. This may put you at higher risk for infections. For as long as you are being treated with Paliperidone, you will need to have regular blood tests done. These blood tests are very important for you. These tests help your doctor to check that your white blood cell counts are within the normal range. Your doctor will advise you about how often you need to have these blood tests.

Paliperidone may also cause your blood sugar levels to rise. Monitor your blood sugar levels more regularly if you have diabetes or a family history of diabetes. Ask your doctor how often you need to have your blood sugar levels monitored.

Paliperidone may affect the ability of your body to adjust to temperature changes in the environment. Avoid exposure to very cold or very hot environments. Avoid strenuous exercise and activities like going to the sauna. Drink more water to prevent dehydration.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your doctor may need to do certain tests to make sure that your heart, lungs, liver, and kidney function is normal before your treatment initiation and thereafter depending on your doctor’s advice.
  • Routine tests (e.g. complete blood count, electrolyte, blood cholesterol/lipid, glucose test, and eye examination) may be done while you are being treated with this medicine. Your doctor will advise you about how often you will need to have these tests.
For as long as you are using this medicine, you may need to regularly monitor your blood pressure and weight.
What side effects could I experience?
Paliperidone may cause drowsiness, dizziness or some problems with your eyesight. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: weight gain, loss of appetite, difficulty sleeping, headache, tremor, cough, stomach pain, nausea, vomiting, constipation, diarrhoea, indigestion, dry mouth, back or joint pain, and injection site reactions such as itching, pain or swelling.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of an allergic reaction e.g. rashes, breathlessness, swelling of the mouth, face, lips, tongue, or throat
  • signs of blood clot in your veins e.g. pain and swelling in your legs
  • signs of stroke e.g. sudden weakness or numbness of your face, arms or legs (especially on one side), slurred speech
  • unusual changes in mood or behaviour (being too depressed, agitated, or having compulsive and impulsive behaviour)
  • signs of tardive dyskinesia e.g. twitching or jerking movements that you cannot control in your face, tongue, or other parts of your body
  • signs and symptoms of heart or blood pressure problems e.g. fast or slow heart rate, irregular heartbeat, lightheadedness or dizziness when you get up from a sitting or lying down position
  • fever or abnormally high body temperature
  • continuous, prolonged, painful erection in men
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for heart disease e.g. amiodarone, sotalol, quinidine, disopyramide
  • medicine for allergies e.g. mizolastine
  • medicine for malaria e.g. mefloquine
  • medicine for epilepsy (fits) e.g. carbamazepine
  • medicine for Parkinson’s disease e.g. levodopa
  • strong painkiller e.g. tramadol
  • other medicine for mood disorders e.g. clozapine
  • medicine for nausea or vomiting e.g. metoclopramide
This list does not include all medicines that may interact with Paliperidone.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store at 25°C. Throw away any portion of the injection that was not used.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on paliperidone - intramuscular and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in