Poisoning due to organophosphate pesticides or related compd. Adjunct to atropine in poisoning due to organophosphate pesticides & chemicals. Overdosage by anticholinesterase drugs used in myasthenia gravis.
Organophosphate poisoning 1-2 g IM/IV, max dose: 12 g/24 hr + atropine 2 mg SC/IM repeated at intervals of 5-60 min. Childn 20-60 mg/kg. Anticholinesterase overdosage1-2 g IV followed by increments of 250 mg every 5 min.