Pantoprazole Beximco

Pantoprazole Beximco

pantoprazole

Manufacturer:

Beximco

Distributor:

Medispec
Concise Prescribing Info
Contents
Pantoprazole
Indications/Uses
20 mg Mild reflux disease & associated symptoms eg, heartburn, acid regurgitation, pain on swallowing. Long-term management & prevention of relapse in reflux oesophagitis. Prevention of nonselective NSAID-induced gastroduodenal ulcer in patients at risk w/ need for continuous NSAID treatment. 40 mg Combination therapy for H pylori eradication in patients w/ peptic ulcer to reduce recurrence of duodenal & gastric ulcer. Moderate & severe reflux esophagitis. Zollinger-Ellison syndrome & other pathological hypersecretory conditions.
Dosage/Direction for Use
20 mg Adult & adolescent ≥12 yr Mild reflux disease & associated symptoms 20 mg daily for 2-4 wk. Healing of associated esophagitis 20 mg daily for 4 wk. Long-term management & prevention of relapse in reflux oesophagitis Maintenance dose: 20 mg daily, may be increased to 40 mg daily if relapse occurs & reduced back to 20 mg after healing. Prevention of NSAID-induced gastroduodenal ulcer in patient at risk 20 mg daily. 40 mg Adult & adolescent ≥12 yr Moderate & severe reflux esophagitis 40 mg daily, may be increased to 80 mg daily. H pylori eradication Adult 40 mg bd + amoxicillin 1,000 mg bd + clarithromycin 500 mg bd or 40 mg bd + metronidazole 500 mg bd + clarithromycin 500 mg bd or 40 mg bd + amoxicillin 1,000 mg bd + metronidazole 500 mg bd. Duration of treatment: 7 days up to max: 2 wk. Duodenal & gastric ulcers 40 mg daily, may be increased to 80 mg daily. Duration of treatment: Duodenal ulcer 2-4 wk. Gastric ulcer & reflux oesophagitis 4-8 wk. Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions Initially 80 mg daily, titrate dose as needed.
Administration
Should be taken on an empty stomach: Take 1 hr before meals. Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity. Co-administration w/ atazanavir. Not to be used in combination treatment for H pylori eradication in patients w/ moderate to severe hepatic or renal dysfunction.
Special Precautions
Not to be used for mild GI complaints eg, nervous stomach. Exclude gastric malignancy prior to therapy. Increased risk of subacute cutaneous lupus erythematosus, osteoporosis-related hip, wrist & spine fractures, Clostridium difficile-associated diarrhea. Presence of any alarm symptom eg, significant unintentional wt loss, recurrent vomiting, dysphagia, haematemesis, anaemia or melaena. Vit B12 malabsorption due to hypo- or achlorhydria; hypomagnesaemia. Discontinue use at least 5 day prior to CgA level measurement. Avoid sun exposure. Prolonged use. Ensure adequate intake of vit D & Ca. Concomitant use w/ digoxin or drugs causing hypomagnesemia eg, diuretics. Pregnancy & lactation. Not recommended in childn <12 yr. Elderly.
Adverse Reactions
Upper abdominal pain, diarrhea, constipation, flatulence, benign fundic gland polyps; headache.
Drug Interactions
Changed absorption of pH-dependent drugs eg, ketoconazole. Reduced bioavailability of atazanavir. Monitor prothrombin time/INR w/ coumarin anticoagulants eg, phenprocoumon or warfarin.
MIMS Class
Antacids, Antireflux Agents & Antiulcerants
ATC Classification
A02BC02 - pantoprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
Presentation/Packing
Form
Pantoprazole Beximco gastro-resistant tab 20 mg
Packing/Price
3 × 10's
Form
Pantoprazole Beximco gastro-resistant tab 40 mg
Packing/Price
3 × 10's
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