Paracetamol + Metoclopramide

Generic Medicine Info
Indications and Dosage
Adult: Each tablet containing paracetamol 500 mg and metoclopramide 5 mg: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 6 tablets/24 hours.
Lactation. Children <12 yr.
Special Precautions
Porphyria, epilepsy, parkinsonism, history of depression, pregnancy. Renal or hepatic impairment. May impair ability to drive or operate machinery. Risk of acute hypersensitivity reactions in patients with phaeochromocytoma. Exclude the possibility of an underlying disorder if patient has persistent vomiting.
Adverse Reactions
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Constipation or diarrhoea; drowsiness, headache, depression, lassitude, extrapyramidal reactions (especially if combined with phenothiazines); galactorrhoea; parkinsonism; neuroleptic malignant syndrome; tardive dyskinesia.
Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage. Metoclopramide: Very rarely, hypertensive crisis in patients with pheochromocytoma. Cardiac conduction disorders (IV admin).
Overdose may cause damage to the liver. May be treated by gastric lavage with supportive measures. IV admin of N-acetylcysteine or oral methionine given within 10 hr of paracetamol overdosage may exert a protective effect on the liver.
Drug Interactions
Action of metoclopramide may be antagonised by anticholinergics and opioid analgesics. Metoclopramide may affect the absorption of orally administered drugs when given together.
Food Interaction
Decreased rate of absorption with food.
Mechanism of Action: Metoclopramide is a dopamine antagonist, which binds to D2 receptors in the central and peripheral nervous system. It has anticholinesterase and antiemetic effects. Paracetamol is a centrally and peripherally acting non-opioid analgesic and antipyretic.
MIMS Class
Antimigraine Preparations
Disclaimer: This information is independently developed by MIMS based on Paracetamol + Metoclopramide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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