Paracetamol + Pentazocine


Concise Prescribing Info
Indications/Uses
Mild to moderate pain.
Dosage/Direction for Use
Adult : PO Per tab contains paracetamol 650 mg and pentazocine 25 mg: 1 tab 4 hrly. Max: 6 tab/day.
Dosage Details
Oral
Mild to moderate pain
Adult: Each tablet containing paracetamol 650 mg and pentazocine 25 mg: 1 tablet every 4 hr. Max: 6 tablets/day.
Contraindications
Hypersensitivity to either component; raised intercranial pressure or head injury.
Special Precautions
Head injury, other intracranial lesions or preexisting increase in intracranial pressure (impedes pupillary response required for neurological assessment); patients on opiate analgesics; opioid dependence; acute alcoholism; compromised respiratory, cardiac, renal or hepatic functions; epileptic patients; pregnancy & lactation, children. Caution when used in patients with MI who have accompanying nausea or vomiting. May experience withdrawal symptoms after receiving pentazocine.
Adverse Reactions
Nausea, vomiting, constipation, anorexia, diarrhea, dizziness, sedation, disorientation, euphoria, headache, visual blurring, rarely dysphoria, sweating, flushing, rashes & urticaria; urinary retention, anaphylactoid reaction & drug abuse & dependence.
Potentially Fatal: Hepatic necrosis (especially in chronic alcoholics).
Overdosage
Symptoms of overdose would be a combination of those observed with pentazocine overdose and paracetamol overdose. Pentazocine overdose may lead to anxiety, nightmares, strange thoughts and hallucinations. Marked respiratory depression associated with increased BP and tachycardia may also occur. Acute paracetamol overdose may cause nausea, vomiting, anorexia and abdominal pain. Severe overdosage may lead to potentially fatal hepatic necrosis. Treatment involves oxygen, IV fluids, vasopressors and other supportive measures.
Drug Interactions
Paracetamol may also enhance anticoagulant activity. Naloxone reverses effects of pentazocine.
Potentially Fatal: Alcohol & other CNS depressants potentiate depressant action of pentazocine.
Action
Description: Pentazocine is an opioid analgesic with agonist/antagonist action. Paracetamol is a centrally and peripherally acting analgesic and antipyretic. The combination gives additive analgesic effects.
Pharmacokinetics:
Absorption: Pentazocine: Well absorbed from the GI tract. Paracetamol: Rapidly and almost completely absorbed from the GI tract.
Distribution: Pentazocine: Passes the placental barrier.
Metabolism: Pentazocine: Metabolised mainly by hepatic biotransformation. Paracetamol: Conjugated in the liver with glucuronic acid and to a smaller extent with sulfuric acid.
Excretion: Pentazocine: Elimination half-life ranges from 1.5-10 hr. Paracetamol: Elimination half-life ranges from 2-4 hr.
Disclaimer: This information is independently developed by MIMS based on Paracetamol + Pentazocine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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