Incompatibilities: This medicinal product must not be mixed with other medicinal products except follitropin alfa.
Special precautions for disposal and other handling: For single use only.
Pergoveris must be reconstituted with the solvent before use.
The reconstituted solution should not be administered if it contains particles or is not clear.
Pergoveris may be mixed with follitropin alfa and coadministered as a single injection.
Any unused medicinal product or waste material should be disposed off in accordance with local requirements.
If administering Pergoveris to oneself, please carefully read the following instructions: Wash hands. It is important that hands and the items to be used are as clean as possible.
Assemble and lay out on a clean surface everything the patient needs: one vial containing Pergoveris powder, one solvent vial, two alcohol swabs, one syringe, one needle for reconstitution and a fine bore needle for subcutaneous injection, sharp container.
Remove the protective cap from the solvent vial. Attach the reconstitution needle to the syringe and draw up some air into the syringe by pulling the plunger to approximately the 1 ml mark. Then, insert the needle into the vial, push the plunger to expel the air, turn the vial upside down and gently draw up all the solvent. Set the syringe down carefully on the work-surface taking care not to touch the needle.
Prepare the injection solution: Remove the protective cap from the Pergoveris powder vial, pick up the syringe and slowly inject the solvent into the vial of powder. Swirl gently without removing the syringe. Do not shake. After the powder has dissolved (which usually occurs immediately), check that the resulting solution is clear and does not contain any particles. Turn the vial upside down, gently draw the solution back into the syringe.
Change the needle for the fine bore needle and remove any air bubbles: If air bubbles are seen in the syringe, hold the syringe with the needle pointing upwards and gently flick the syringe until all the air collects at the top. Push the plunger until the air bubbles are gone.
Immediately inject the solution: The doctor or nurse will have already advised where to inject (e.g. tummy, front of thigh). Wipe the chosen area with an alcohol swab. Firmly pinch the skin together and insert the needle at a 45° to 90° angle using a dart-like motion. Inject under the skin, as were taught. Do not inject directly into a vein. Inject the solution by pushing gently on the plunger. Take as much time as needed to inject all the solution. Immediately withdraw the needle and clean the skin with an alcohol swab using a circular motion.
Dispose off all used items: Once finished with the injection, immediately discard all needles and empty glass containers in the sharp container provided. Any unused solution must be discarded.