HTN 4 mg once daily, may be increased to 8 mg once daily after 1 mth of treatment. Elderly Initially 2 mg once daily, may be progressively increased to 4 mg after 1 mth & then to 8 mg once daily if necessary. Symptomatic heart failure Initially 2 mg once daily, may be increased by 2 mg-increments at intervals of ≥2 wk to 4 mg once daily if tolerated.
Should be taken on an empty stomach.
History of angioedema associated w/ previous ACE inhibitor therapy; hereditary or idiopathic angioedema. 2nd or 3rd trimester of pregnancy.
Vol or salt depletion, bilateral renal artery stenosis or artery stenosis to solitary kidney, ischaemic heart or cerebrovascular disease, mitral valve stenosis, left ventricular outflow obstruction (eg, aortic stenosis or hypertrophic cardiomyopathy), patients dialysed w/ high flux membranes. Patients undergoing major surgery or during anaesth w/ agents that cause hypotension. Uncontrolled DM. Renal impairment. Pregnancy & lactation.