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Indications/Uses
Listed in Dosage.
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Dosage/Direction for Use
Adult : Topical Head pediculosis As 1% lotion (creme rinse): Apply sufficient amount to saturate washed and towel-dried hair and scalp, leave on for 10 min before rinsing. May be repeated after 7-10 days if necessary. Scabies As 5% cream: Apply a thin layer approx 30 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing.
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Dosage Details
Topical/Cutaneous
Scabies Adult: As 5% cream: Apply a thin layer approx 30 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing. Child: 2 mth to <1 yr Apply a thin layer approx 3.75 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing. ≥1-5 yr Apply approx 7.5 g. 6-12 yr Apply approx 15 g. >12 yr Same as adult dose. Topical/Cutaneous Head pediculosis Adult: As 1% lotion (creme rinse): Apply sufficient amount to saturate washed and towel-dried hair and scalp, leave on for 10 min before rinsing. May be repeated after 7-10 days if necessary.
Child: ≥6 mth Same as adult dose. |
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Contraindications
Hypersensitivity.
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Significant: Skin and scalp irritation (e.g. itching, redness, swelling).
Dermatologic: Burning, numbness, stinging, tingling, rash, erythema, pruritus, eczema, localized oedema. |
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Topical: B
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Patient Counseling Information
Avoid contact w/ eyes, mucous membranes and broken skin.
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Action
Description: Permethrin is a pyrethroid or pyrethrin pediculocide and scabicide. It disrupts Na ion influx through the nerve cell membrane channels, delaying repolarisation thus causing paralysis and death of the parasites.
Pharmacokinetics: Absorption: Minimally absorbed from the skin. Metabolism: Rapidly metabolised in the liver via ester hydrolysis into inactive metabolites. Excretion: Via urine. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Permethrin, CID=40326, https://pubchem.ncbi.nlm.nih.gov/compound/Permethrin (accessed on Jan. 22, 2020) |
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Storage
Store between 20-25°C.
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MIMS Class
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ATC Classification
P03AC04 - permethrin ; Belongs to the class of pyrethrines, including synthetic compounds used as ectoparasiticides.
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References
Anon. Permethrin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/10/2017. Buckingham R (ed). Permethrin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/10/2017. Joint Formulary Committee. Permethrin. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/10/2017. Lice Treatment Lotion (Walgreen Company). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/10/2017. McEvoy GK, Snow EK, Miller J et al (eds). Permethrin (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/10/2017. Nix Shampoo (Insight Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/10/2017. Permethrin Cream (NuCare Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/10/2017.
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