Permethrin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Head pediculosis As 1% lotion (creme rinse): Apply sufficient amount to saturate washed and towel-dried hair and scalp, leave on for 10 min before rinsing. May be repeated after 7-10 days if necessary. Scabies As 5% cream: Apply a thin layer approx 30 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing.
Dosage Details
Topical/Cutaneous
Scabies
Adult: As 5% cream: Apply a thin layer approx 30 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing.
Child: 2 mth to <1 yr Apply a thin layer approx 3.75 g onto skin surface from the head to the soles of the feet, leave on for 8-14 hr before rinsing. ≥1-5 yr Apply approx 7.5 g. 6-12 yr Apply approx 15 g. >12 yr Same as adult dose.

Topical/Cutaneous
Head pediculosis
Adult: As 1% lotion (creme rinse): Apply sufficient amount to saturate washed and towel-dried hair and scalp, leave on for 10 min before rinsing. May be repeated after 7-10 days if necessary.
Child: ≥6 mth Same as adult dose.
Contraindications
Hypersensitivity.
Special Precautions
Pregnancy and lactation.
Adverse Reactions
Significant: Skin and scalp irritation (e.g. itching, redness, swelling).
Dermatologic: Burning, numbness, stinging, tingling, rash, erythema, pruritus, eczema, localized oedema.
Patient Counseling Information
Avoid contact w/ eyes, mucous membranes and broken skin.
Action
Description: Permethrin is a pyrethroid or pyrethrin pediculocide and scabicide. It disrupts Na ion influx through the nerve cell membrane channels, delaying repolarisation thus causing paralysis and death of the parasites.
Pharmacokinetics:
Absorption: Minimally absorbed from the skin.
Metabolism: Rapidly metabolised in the liver via ester hydrolysis into inactive metabolites.
Excretion: Via urine.
Chemical Structure

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Storage
Store between 20-25°C.
ATC Classification
P03AC04 - permethrin ; Belongs to the class of pyrethrines, including synthetic compounds used as ectoparasiticides.
Disclaimer: This information is independently developed by MIMS based on Permethrin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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