Pharmaniaga Atropine Sulphate

Pharmaniaga Atropine Sulphate

atropine

Manufacturer:

Pharmaniaga Manufacturing Berhad

Distributor:

Pharmaniaga Logistics
Concise Prescribing Info
Contents
Atropine sulphate
Indications/Uses
Pre-anaesth medication in conjugation w/ morphine sulphate. Reverse the effects of non-depolarising muscle relaxants in conjugation w/ neostigmine methyl sulphate. Smooth muscle spasm in conditions eg, renal & biliary colic. Management of arrhythmias & treatment of bradycardia or asystole due to overdosage w/ parasympathomimetic agents. Suppression of GI motility in the treatment of peptic ulcer. Diagnosis of colicky pain. Antidote in carbamate & w/ pralidoxime in organophosphorus insecticide poisoning.
Dosage/Direction for Use
IV Management of arrhythmias 400 mcg-1 mg, repeated as needed to a total dose of 2 mg. SC/IM/IV Bradycardia or asystole due to overdosage w/ parasympathomimetic agents 1-2 mg. IV/IM Anticholinesterase poisoning 1-2 mg initial dose for mild poisoning; 6 mg as often as every 5 min for severe poisoning. SC/IM/IV Adult GI anticholinergic effect 400-600 mcg qds. Pre-anaesth medication 300-600 mcg 1 hr before induction. SC Childn 10 mcg/kg every 4-6 hr (w/ reduced doses on hot days or for a febrile child).
Contraindications
Closed-angle glaucoma, gastric or duodenal ulcer causing stenosis & significant gastric retention, urinary retention in prostatic hypertrophy, paralytic ileus, debilitated patients w/ oesophageal reflux or oesophagitis. Situations where ambient temp is high since hyperpyrexia may follow, especially in childn. Patients w/ myasthenia gravis unless to reduce adverse muscarinic effects. Lactation.
Special Precautions
Tachycardia eg, thyrotoxicosis, cardiac insufficiency or failure & in cardiac surgery. HTN, fever, diarrhoea, acute MI. Childn. Elderly.
Adverse Reactions
Mouth dryness w/ difficulty in swallowing, thirst, dilated pupils w/ accommodation loss & photophobia, increased IOP, flushing & skin dryness, bradycardia followed by tachycardia w/ palpitations & arrhythmias, urinary retention, constipation, occasional vomiting, giddiness & staggering. Rapid & stertorous respiration, hyperpyrexia, restlessness, confusion & excitement, hallucinations passing into delirium, rash (may appear on face & upper trunk).
Drug Interactions
Enhanced effect w/ other antimuscarinic agents eg, amantadine, some antihistamines, butyrophenones, phenothiazines & TCAs.
ATC Classification
A03BA01 - atropine ; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Pharmaniaga Atropine Sulphate soln for inj (amp) 1 mg/mL
Packing/Price
1 mL x 10 × 1's
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