Pharmaniaga Fentanyl

Pharmaniaga Fentanyl



Pharmaniaga LifeScience


Pharmaniaga Logistics
Concise Prescribing Info
Short-acting analgesia in surgical procedures. Adjunct in general anaesth maintenance. In combination w/ neuroleptic agent in neuroleptanalgesia technique. Resp depressant/analgesic in patients requiring prolonged assisted ventilation. Anaesth induction.
Dosage/Direction for Use
Adult & childn 12-17 yr Neurolept analgesia Initially 50-100 mcg slow IV inj in combination w/ neuroleptic, may be given 2nd dose of 50-100 mcg 30-45 min after initial dose. Neuroleptic anaesth Initially 200-600 mcg slow IV inj in combination w/ neuroleptic. Maintenance: Additional 50-100 mcg every 30-45 min. Premed anaesth 50-100 mcg IM 30-60 min pre-op. Anaesth induction Initially 70-600 mcg. Anaesth maintenance Additional 25-100 mcg inj subsequently. Pain management in ICU Initially 50-100 mcg IV followed by repeated inj up to total: 25-125 mcg hrly. Childn 2-11 yr Spontaneous respiration & assisted ventilation Initially 1-2 mcg/kg. Supplemental dose: 1-1.25 mcg/kg.
Hypersensitivity to fentanyl & other morphinomimetics. Resp depression w/o artificial ventilation; increased intracranial pressure & brain trauma; hypovolaemia & hypotension; myasthenia gravis. Concomitant or w/in 2 wk of MAOI therapy.
Special Precautions
Not to be administered as fast bolus inj. History of opioid abuse. Uncompensated hypothyreosis, lung diseases especially w/ reduced vital capacity, alcohol abuse; adrenal insufficiency, prostatic hypertrophy, porphyria, bradyarrhythmia; inflammatory or obstructive intestinal diseases; hypovolaemia, decompensated heart failure. Muscle rigidity leading to resp depression. Intra-op diagnostic procedure in bile duct surgery; pain management of intensive care patients. Combination w/ nonvagolytic muscle relaxants; droperidol. May affect ability to drive & use machines. Hepatic & renal impairment. Not to be used during pregnancy & lactation. Neonates. Elderly & weak patients.
Adverse Reactions
Resp depression, apnoea, laryngospasm, bronchospasm, pulmonary oedema; vertigo, euphoria, nausea, vomiting; movement disturbances, increased sensitiveness, w/drawal symptoms in childn; bradycardia, cardiac arrest, decreased BP, orthostatic regulatory disturbances; muscle rigidity; constipation, urinary retention, Oddi sphincter spasm, miosis, visual disturbances; anaphylaxis, pruritus, urticaria, sweating, singultus; methemoglobinemia.
Drug Interactions
Augmented resp depression w/ barbiturates, benzodiazepines, neuroleptics, halogen-containing volatile anaesth or other drugs w/ nonselective CNS depressant effect ie, alcohol. Impaired CV function w/ nitrous oxide or diazepam. Decreased BP w/ midazolam. Fall/rise in BP w/ droperidol. Intensified & prolonged effect w/ MAOIs. Increased plasma levels w/ cimetidine. Enhanced effects w/ clonidine, baclofen. Haemodynamic depression w/ vecuronium. Bradycardia w/ atracurium. Increased metabolism w/ anticonvulsants ie, carbamazepine, phenytoin, primidone; potent CYP3A4 inhibitors eg, fluconazole, ketoconazole, erythromycin, diltiazem. Reduced clearance by ritonavir. Incompatibility w/ pentobarbital Na, methohexital Na, thiopental Na, nafcillin.
MIMS Class
Analgesics (Opioid)
ATC Classification
N01AH01 - fentanyl ; Belongs to the class of opioid anesthetics. Used as general anesthetics.
Pharmaniaga Fentanyl soln for inj 50 mcg/mL
2 mL x 10 × 1's
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