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Although furosemide is used in high doses for oliguria due to chronic or acute renal impairment, it should not be given in anuria or in renal failure caused by nephrotoxic or hepatotoxic drugs nor in renal failure associated with hepatic coma. Furosemide should not be given in pre-comatose states associated with cirrhosis. It should be used with care in patients with prostatic hyperplasia or impairment of micturition since it can precipitate acute urinary retention.
To reduce the risk of ototoxicity, furosemide should not be injected intravenously at a rate exceeding 4mg/minute.
