Pharmaniaga Labetalol HCl

Pharmaniaga Labetalol HCl

labetalol

Manufacturer:

Pharmaniaga LifeScience

Distributor:

Pharmaniaga Logistics
Concise Prescribing Info
Contents
Labetalol HCl
Indications/Uses
Severe HTN in pregnancy. Hypotensive anaesth. Hypertensive episodes following acute MI.
Dosage/Direction for Use
Severe HTN in pregnancy Initially 20 mg/hr then doubled every 30 min until satisfactory response is obtained or 160 mg/hr is reached. HTN due to other causes 2 mg/min until satisfactory response is obtained. Dose range: 50-200 mg. Hypotensive anaesth Initially 10-20 mg IV, may be increased in 5-10 mg increments until desired BP level is attained. Hypertensive episodes following acute MI Initially 15 mg/hr, gradually increased to max: 120 mg/hr.
Contraindications
Hypersensitivity. 2nd or 3rd degree heart block, cardiogenic shock & other conditions associated w/ severe & prolonged hypotension or severe bradycardia. Asthma or history of obstructive airway disease. Peripheral vasoconstriction suggesting low cardiac output.
Special Precautions
History of severe anaphylactic reaction. Discontinue use if evidence of hepatic injury or jaundice is observed. Peripheral vascular disease, symptomatic bradycardia, 1st-degree AV block. Heart failure or poor left ventricular systolic function; phaeochromocytoma. May mask compensatory physiological responses of sudden haemorrhage & hypoglycemia symptoms in diabetic patients & thyrotoxicosis. Maintain blood vol. Concomitant administration w/ adrenaline; α1-blockers. Hepatic impairment. Pregnancy.
Adverse Reactions
Symptomatic postural hypotension. Ventricular arrhythmia; dizziness, scalp/skin tingling, hypoesthesia, vertigo; nausea, vomiting, dyspepsia, taste distortion; increased BUN & serum creatinine; somnolence/yawning; wheezing; pruritus.
Drug Interactions
Enhanced hypotensive effects of halothane. Reduced hypotensive effect w/ NSAIDs. Reduced uptake of metaiodobenzylguanidine radioisotopes. Enhanced digoxin effect in reducing ventricular rate. Bradycardia & HTN w/ adrenaline. Class I antiarrhythmics or verapamil-type Ca antagonists. Interfered w/ certain fluorescent substances assay. Falsely elevated urinary catecholamine levels.
MIMS Class
Beta-Blockers
ATC Classification
C07AG01 - labetalol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Pharmaniaga Labetalol HCl inj 25 mg/5 mL
Packing/Price
10 × 1's
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