Pharmaniaga Labetalol HCl

Pharmaniaga Labetalol HCl Drug Interactions



Pharmaniaga LifeScience


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Full Prescribing Info
Drug Interactions
Labetalol hydrochloride injection may enhance the hypotensive effects of halothane.
Care should be taken if Labetalol is used concomitantly with either Class I antiarrhythmic agents or calcium antagonists of the verapamil type.
The hypotensive effect of Labetalol hydrochloride injection may be reduced when used in combination with prostaglandin synthetase inhibitors (NSAIDs). Dosage adjustments may therefore be necessary.
Labetalol hydrochloride injection fluoresces in alkaline solution at an excitation wavelength of 334 nm and a fluorescence wavelength of 412 nm and may therefore interfere with the assays of certain fluorescent substances including catecholamines.
The presence of Labetalol metabolites in the urine may result in falsely elevated levels or urinary catecholamines, Metanephrine, Normetanephrine, and Vaillylmandelic acid (VMA) when measured by fluorimetric or photometric methods. In screening patients suspected of having a pheochromocytoma and being treated with Labetalol hydrochloride, a specific method, such as a high performance liquid chromatographic assay with solid phase extraction should be employed in determining levels of catecholamines.
Labetalol has been shown to reduce the uptake of radioisotopes of Metaiodobenzylguanidine (MIBG). Care should therefore be taken in interpreting results from MIBG scintigraphy.
Labetalol hydrochloride injection may enhance digoxin's effect of reducing ventricular rate.
Concomitant administration of Labetalol with Adrenaline may result in bradycardia and hypertension.
Incompatibilities: Pharmaniaga Labetalol hydrochloride 25mg/5mL Injection is incompatible with Sodium bicarbonate injection 4.2% W/V.
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