The use of this medicine is contraindicated in the following cases: hypersensitivity to gliclazide or other sulphonylureas or sulphonamides, or to any of the excipients used, insulin-dependent diabetes (type 1 diabetes), diabetic pre-coma and coma, diabetic ketoacidosis, severe hepatic or renal insufficiency; in this cases, the use of insulin is recommended; treatment with miconazole; lactation.