Felodipine can, like other vasodilators, cause hypotension. This may, in susceptible patients, result in myocardial ischemia.
Mild gingival enlargement has been reported in patients with pronounced gingivitis/periodontitis. The enlargement can be avoided or reversed by careful dental hygiene.
Felodipine is eliminated by the liver. Therefore, higher therapeutic concentrations and a higher treatment response may be expected in patients with clearly impaired hepatic function.
Plendil contains lactose and should not be given to patients with hereditary galactose intolerance or glucose-galactose malabsorption.
Effects on Ability to Drive and Use Machines: Felodipine is not likely to affect the ability to drive or use machines.
Fertility: Data on male and female fertility in patients are missing (see Pharmacology: Toxicology: Preclinical Safety Data under Actions).