5 g (2 x 2.5 g/50 mL) IV as 2 consecutive infusions over 5-10 min each or as bolus inj. Bleeding recurrence/potential life-threatening re-bleeding/2nd emergency surgery/urgent procedure w/ prolonged clotting time
2nd 5-g dose may be
considered. Restarting antithrombotic therapy
Reinitiated after 24 hr & other antithrombotic therapy eg, LMWH may be started at any time if clinically stable & adequate hemostasis has been achieved.